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Predicting the stability of crystalline materials is essential for developing advanced materials and pharmaceuticals. Researchers developed a new thermodynamic integration framework that calculates Gibbs free energies entirely under constant-pressure conditions, improving accuracy while simplifying the workflow. The method was validated using ice polymorphs and CsPbI₃ and relied on more than 10,000 GPU hours on VSC infrastructure.

Researchers at VUB developed a patient-relevant orthotopic lung cancer model and combined SEPARATE-Seq with spatial transcriptomics to map the immune landscape of lung tumours. Supported by VSC's high-performance computing infrastructure, the study provides new insights into immune cell behavior and offers a valuable resource for cancer immunology and future therapy development.

The VSC Tier-1 supercomputer sofia has made a strong international debut, ranking 222nd in the TOP500 list of the world's most powerful supercomputers and 41st in the Green500 ranking for energy efficiency. Hosted by VUB at the Nexus Datacenter in Zellik, sofia combines advanced computing power with a strong focus on sustainability. Starting in July 2026, it will support Flemish researchers in AI, climate science, medical research, and large-scale simulations.

The Flemish Supercomputer Center (VSC) has published its Annual Report 2025, highlighting a year of major milestones, including the inauguration of sofia, VSC's next-generation Tier-1 supercomputer. The report showcases how VSC continues to support cutting-edge research, AI, and innovation through advanced computing infrastructure, expert support, training, and European collaborations. Discover the achievements, impact, and future ambitions shaping the HPC landscape in Flande

Highlights from the KU Leuven/UHasselt HPC User Day 2026, featuring the inauguration of the new Tier-2 supercomputer, hands-on training sessions, research testimonials, and community networking.

Brain activity measured with EEG offers a non-invasive way to study cognitive function. This research uses machine learning and brain connectivity patterns to detect Alzheimer’s disease and frontotemporal dementia, two conditions that are difficult to distinguish clinically. The approach improves diagnostic insights while highlighting the role of brain networks in neurodegenerative disorders.

Inside the VSC Support Team, Alex Domingo shares how effective guidance, clear documentation, and strategic planning help researchers turn challenges into solutions. From software installations to workflow optimization, discover how VSC support empowers users across Flanders to make the most of HPC infrastructure and drive their research forward with confidence.

Using large-scale molecular dynamics simulations, this research quantifies the self-diffusivity of boron in high-temperature CaO–SiO₂–Al₂O₃ slags relevant to silicon recycling. Enabled by VSC Tier-1 supercomputing resources, the study provides diffusion values consistent with diffusion-controlled experiments and clarifies the role of convection in industrial and laboratory systems.

Cancer cells evolve over time through genetic mutations that enable them to adapt, survive therapy, and become drug resistant. Understanding these evolutionary processes at high resolution is essential for developing more effective, targeted cancer treatments.

VSC has unveiled sofia, the new Flemish Tier-1 supercomputer hosted at the VUB Nexus Datacenter in Zellik. With high energy efficiency, strong GPU performance, and broad applications across science and industry, sofia marks a major step forward for research and innovation in Flanders. Explore the full story, technical details, and media coverage in our latest update.