High-performance computing (HPC) started to gain traction in the 1990s with the introduction of massively parallel computer systems. Thanks to steadily increasing compute power and widespread availability of HPC infrastructure, HPC quickly became an essential component in nearly every field of scientific research. HPC is now firmly established as the third pillar of modern research, alongside theory and experimentation.

HPC applications can be roughly divided into three classes.

In the first class, modelling and simulation, computer-based models are used as simplified versions of the real-world, reducing the need for costly and time-consuming experiments and allowing the study of physical or chemical properties under conditions that are impossible to test experimentally. Big applications of this class are found in molecular simulation, computational fluid dynamics and climate prediction models, among others.

High-performance data analytics or HPDA, the second class, unites HPC with data analytics. It involves parallel processing of large datasets, which may originate from experiments, simulations, or publicly available databases. HDPA is heavily applied in fields such as high-energy particle physics, genomics and proteomics, and optical imaging.

More recently artificial intelligence, and in particular machine learning, is rapidly gaining momentum as a third HPC class. This growing trend is made possible in large part by the wide availability of graphical processing units or GPUs and the development of new algorithms that are able to take advantage of the 1000s of cores on these GPUs.

Whenever sufficient amounts of training data are available artificial intelligence can be applied, including bioinformatics, linguistics, medical diagnosis, and astrophysics.

Some research accomplishments on our systems

Mechanistic modeling and in silico evolution of gene regulatory networks

Evolutionary Systems Biology lab (VIB, UGent) develops a computational model of a gene regulatory network, offering new insights on the evolution and function of complex biological systems.

Modeling brain dynamics in health and disease using supercomputing

Prof. Daniele Marinazzo (UGent) uses supercomputing to model the brain’s function in health and disease.

Molecular modeling spurs innovative technology against global warming

Relying on computational research, the Center for Molecular Modeling is able to present a new, cheaper technology that removes CO2 from exhaust gases by using the waste heat of these gases.

Regional climate studies

Climate research is about uncovering all elements that influence the climate and discovering the way they interact. Computational modelling on HPC systems is a crucial part of this research.

Research on the dynamical interaction between plasmas and magnetic fields

The Centre for mathematical Plasma Astrophysics (CmPA) @ KU Leuven concentrates its research on the dynamical interaction between plasmas and magnetic fields.

Simulation of plasma - surface interactions

Computational modelling and simulation is a vital tool in the study of the structure and chemical reactivity of nanomaterials and biomolecules. These computational studies are not feasible without the



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